研究领域(方向)
复杂体系中抗过敏活性成分筛选发现
抗过敏性药物发现与机制研究
过敏性疾病的发生机制
个人及工作简历
个人受教育及工作经历
2004.9-2008.7陕西师范大学本科
2009.9-2014.12西安交通大学博士
2014.12-2018.6西安交通大学讲师
2016.12-2017.12约翰∙霍普金斯大学访问学者
2018.6至今西安交通大学副教授
科研项目
1.国家自然科学基金青年项目1项(2015-2017)
2.国家博士后基金面上项目2项(2016-2018,2019-2021)
3.陕西省自然科学基金青年项目1项(2015-2016)
4.中央高校基本科研业务费1项(2018-2020)
学术及科研成果、专利、论文
以第一及通讯作者发表SCI论文18篇,申请专利6项,授权2项。
近年发表部分SCI论文如下:
1.Nan Wang, Langchong He*, et al. Imperatorin ameliorates mast cell-mediated allergic airway inflammation by inhibiting MRGPRX2 and CamKII/ERK signaling pathway. Biochemical Pharmacology. 2021, 184: 114401.
2.Nan Wang, Shengli Han, Rui Liu, Liesu Meng, Huaizhen He, Shemin Lu*, Langchong He* et al. Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus. Phytomedicine. 2020, 79: 153333.
3.Jue Wang, Nan Wang*, et al. Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation. Phytotherapy Research. 2020, 34: 2985-2997.
4.Yingnan Zeng, Nan Wang*, et al. Gold induces a pseudo-allergic reaction via MRGPRX2 bothin vitroandin vivo. Cellular Immunology 2019, 341: 103923.
5.Jue Wang, Nan Wang*, et al. Baicalin induces Mrgprb2-dependent pseudo-allergy in mice. 2020. Immunology Letters. 2020, 226: 55-61.
6.Yongjing Zhang, Nan Wang*, et al. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2. Virology. 2020, 16: 83-88.
7.Rui Liu, Nan Wang*, et al. Relationship between MRGPRX2 and pethidine hydrochloride- or fentanyl citrate-induced LAD2 cell degranulation. Journal of pharmacy and pharmacology.
8.Yongjing Zhang, Nan Wang*, et al. Roxithromycin inhibits compound 48/80-induced pseudo-allergy via the MrgprX2 pathway both in vitro and in vivo. Cellular Immunology.
9.Yongjing Zhang, Nan Wang*, et al. Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2.Virology. 2020, 554: 83–88.
10.Shiling Hu, Nan Wang*, Langchong He*, et al. Three salvianolic acids inhibit 2019‐nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2. Journal of Medical Virology. 2021:1–9.
11.Wang Jue;Zhang Yongjing;Hu Shiling;Ge Shuai;Jia Min;Wang Nan.Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. International immunopharmacology. 2021, 93:107426.
联系方式
电子邮箱:wangnan2014@xjtu.edu.cn
联系电话:
个人主页:http://gr.xjtu.edu.cn/web/wangnan2014
联系地址:西安市长安区钓台街道中国西部创新港21号楼5103